Adenosine deaminase (ADA), a key enzyme in purine metabolism, has been implicated in tumor progression and immune evasion, yet its role in pediatric NHL remains underexplored.<h4>Methods</h4>This retrospective study included 215 pediatric NHL patients categorized into precursor cell lymphoma (n = 88) and mature cell lymphoma (n = 127) groups based on pathology. This evidence concerns the gene ADA and non-Hodgkin lymphoma.