For fibrosis, HLA-DRB1*15 showed the strongest trend-level association (OR ~2.6-2.9) but did not remain significant after correcting for multiple testing.<h4>Conclusions</h4>In this RA cohort, metabolic factors (particularly BMI and triglycerides) were the dominant predictors of CAP-defined steatosis. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.