Eligible studies assessed oxidative stress biomarkers in biological samples from patients with silicosis and non-exposed controls.<h4>Results</h4>Malondialdehyde (MDA) and Superoxide Dismutase (SOD) were the most frequently assessed oxidative and antioxidant markers, respectively, with MDA significantly increased and SOD decreased in patients with silicosis, highlighting amplified lipid peroxidation and impaired antioxidant defense. This evidence concerns the gene SOD1 and silicosis.