The complex interactions between PD symptoms and the EPHA1 protein warrant further exploration.<h4>Methods</h4>A cohort of 509 participants, including 362 normal controls (NCs) and 147 PD patients, was included and genotyped for the ephrin type-A receptor 1-antisense 1 (EPHA1-AS1) gene. Here, EPHA1 is linked to Parkinson disease.