Furthermore, PD was a significant moderator of the association between rs2966700 and the positive subscore (p = 0.001), with PD patients carrying the C allele performing worse.<h4>Conclusions</h4>This study offers new insights into the interaction between the EPHA1-AS1 gene and PD, thereby enhancing our understanding of its impact on social cognition, particularly in recognizing positive emotions in individuals with PD. Here, EPHA1 is linked to Parkinson disease.