MAPT and AL amyloidosis: It identified %ptau217 as the best predictor of amyloid PET status, generated a plasma proteomic survival model with performance comparable to published models, proposed a mechanism linking tau pathology to altered lysosomal acidification, and generated multiple myeloma hypotheses that were validated in an external cohort while distinguishing true signal from randomized controls.<h4>Conclusion</h4>OpenScientist demonstrates that open, auditable, agentic AI can support real-world clinical research by generating hypotheses, executing analyses, and discovering insights from complex datasets.