This research aims to elucidate the molecular pathways connecting obesity to hypertension in pediatric populations, with a focus on the gene S100A9 (S100 Calcium Binding Protein A9), implicated in inflammatory responses and vascular dysfunction.<h4>Methods</h4>We analyzed gene expression data from GSE87493 dataset and performed Weighted Gene Co-expression Network Analysis (WGCNA) to identify the differentially expressed genes (DEGs) and co-expression modules associated with childhood obesity. This evidence concerns the gene S100A9 and Hypertension.