Causal analyses supported cg08227773 methylation-mediated effects on both coronary artery disease risk (P<sub>SMR</sub>=2.91E-05, coloc PP.H4 =0.91) and <i>NBEAL2</i> (Neurobeachin-like 2) expression (P<sub>SMR</sub>=9.13E-08, coloc PP.H4=0.69), a gene implicated in immune dysregulation. The gene discussed is NBEAL2; the disease is coronary artery disorder.