ADAM9 and neoplasm: In spheroid models, ADAM9 depletion prevented TAM-mediated spheroid destabilization and suppressed collective invasion.<h4>Conclusion</h4>These findings identify ADAM9 as a key effector of TAM-driven tumor invasion through ECM remodeling and cytoskeletal regulation, and highlight ADAM9 as a promising therapeutic target within the tumor immune microenvironment.