Therefore, the occasional detection of MOG antibodies in patients with CNS-cGVHD may represent a manifestation within the spectrum of CNS-GVHD.<h4>Case presentation</h4>A 22-year-old female with severe aplastic anemia (AA) underwent maternal haploidentical hematopoietic stem cell transplantation (HSCT) in May 2021. Here, MOG is linked to graft versus host disease.