TNFAIP3 and A20 haploinsufficiency: The clinical, genetic characteristics and treatment methods of five children with HA20 from different families were collected from Henan Children's Hospital between April 2019 and August 2023 to evaluated for accumulating experience in the management of this rare condition.<h4>Results</h4>We identified five heterozygous variants in the <i>TNFAIP3</i> gene among the five children, including c.866delA: p.H289Pfs* 3, c.1243_1247delAAAAC: p. N416Tfs* 11, NC_000006.11: g.136693638_138817508del, c.133C>T: p.R45X, c.1903_1906delAAAC: p. K635fs* 61.