NLRC5, the largest NLR family member, is a direct m<sup>6</sup>A target of METTL3, but its role in METTL3-driven renal fibrosis remains unclear.<h4>Methods</h4>An <i>in vitro</i> renal fibrosis model was established using TGF-β1-stimulated human proximal tubular (HK-2) cells. This evidence concerns the gene NLRC5 and renal fibrosis.