Blood obtained at 12 and 44 weeks postpartum was used to compare functional and phenotypic characteristics of unstimulated and TB-stimulated CD4+ and CD8+ conventional T cells (Tconv); unconventional T cells, including γδ, iNKT, MR1+ and MR1- MAIT, and NKT; NK; and antigen presenting cells (APC) pre- and post-TPT.<h4>Results</h4>In 45 participants with medians of 477 CD4+ T cells/μL and <50 HIV RNA copies/mL of plasma on antiretroviral therapy, both Tconv and innate immune cells responded to TB antigenic stimulation <i>in vitro</i> with an increase in functional markers. The gene discussed is CD4; the disease is tuberculosis.