Inosine inhibits the activation of the PI3K/AKT signaling pathway.<h4>Discussion</h4>Inosine exerted an inhibitory effect on colorectal cancer liver metastasis by skewing macrophages toward an M1 phenotype, dampening pro-inflammatory cytokine release, and regulating key genes via the PI3K/AKT pathway. Here, AKT1 is linked to colorectal cancer.