Neuronal astrocytes rely on a cytoskeletal element known as glial fibrillary acidic protein (GFAP), which facilitates their main structural framework, maintaining neurological function, repair, and lastly the blood-brain barrier. Pathologies such as neoplasms, autoimmune-mediated inflammation, and even genetic dysfunction can directly harm this element and result in malfunctioning astrocytes, CNS inflammation, and cell death. The gene discussed is GFAP; the disease is neoplasm.