Metabolic hormones (insulin, leptin, adiponectin), fasting glucose, age, and anthropometrics were assessed and included in multivariable models.<h4>Results</h4>Males with obesity exhibited higher FSH (<i>P</i> = 0.002), lower inhibin b (<i>P</i> = 0.004) and lower SHBG (<i>P</i> < 0.0001). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.