However, the influence of obesity on adult male reproductive health in Samoa is poorly understood.<h4>Objectives</h4>To determine if reproductive hormone levels differed between adult Samoan males with and without obesity.<h4>Methodology</h4>Reproductive hormones (follicle stimulating hormone [FSH], luteinizing hormone [LH], inhibin b) and sex hormone binding globulin (SHBG) were compared between non-diabetic adult males in Samoa with and without obesity to test the hypothesis that obesity is associated with compromised reproductive function in this population. The gene discussed is PLOD1; the disease is obesity due to melanocortin 4 receptor deficiency.