Real-time PCR, western blotting, and glucose-stimulated insulin secretion (GSIS) assays were employed to analyze insulin expression and insulin secretion activity in β-cell lines.<h4>Results</h4>1) Clinical data showed that Proband 1 presented with insulin dependence, severe hyperlipidemia, diabetic retinopathy, and cataract at the initial stage of the disease. Here, INS is linked to hyperlipidemia.