Cox regression showed atrial fibrillation (HR = 1.95, 95%CI 1.35-2.80), diabetes (HR = 1.32, 95%CI 1.02-1.70), and prothrombin activity (HR = 1.01, 95%CI 1.00-1.01) as independent risk factors. This evidence concerns the gene F2 and atrial fibrillation.