We identified 904 studies; from them, 33 full texts were eligible, and 18 studies were included in the meta-analysis.<h4>Results</h4>GLP-1 agonists achieved a higher reduction in weight, HbA1c, and time spent in hyperglycemia compared to controls, MD=-4.28, 95% <i>CI</i>, -5.06--3.49, MD=-0.4, 95% <i>CI</i>, -0.77--0.03, and MD=-1.98, 95% <i>CI</i>, -3.68--0.28, respectively. Here, GCG is linked to Hyperglycemia.