CD44 and Autoimmunity: In the current study, we determined that a novel class of donor-derived CD8<sup>+</sup>CD44<sup>+</sup>CD122<sup>+</sup> Tregs (d-CD8<sup>+</sup>CD122<sup>+</sup> Tregs) plays a crucial role in controlling autoimmunity in non-obese diabetic (NOD) mice with induced mixed chimerism.