PIK3R3 and keloid: RT-qPCR confirmed PIK3R3 upregulation in keloids, though ANGPTL5 results were inconsistent, possibly due to sample limitations.<h4>Conclusion</h4>This study, based on the integrated re-analysis of existing publicly available transcriptomic data and combined with clinical sample validation, revealed the potential hub roles of PIK3R3 and ANGPTL5 in keloid pathogenesis.