EPAS1 and renal cell carcinoma: Previous genome-wide association studies (GWAS) have identified risk single nucleotide polymorphisms (SNPs) associated with RCC susceptibility, particularly within genes such as <i>ITPR2</i>, <i>DPF3</i>, <i>EPAS1</i>, <i>PVT1</i>, and <i>MYC</i>.