Validation of &lt;i&gt;ITPR2&lt;/i&gt;, &lt;i&gt;DPF3&lt;/i&gt;, &lt;i&gt;EPAS1&lt;/i&gt;, and &lt;i&gt;PVT1&lt;/i&gt;-associated SNPs as biomarkers for RCC in an independent case-control cohort. This evidence concerns the gene EPAS1 and renal cell carcinoma.