These pathways are highly relevant to RCC pathogenesis, although the functional significance of these genetic variations in sporadic RCC remains insufficiently characterized.<h4>Methods</h4>This study analyzed five GWAS-identified SNPs-rs1049380 and rs10771279 (<i>ITPR2</i>), rs4903064 (<i>DPF3</i>), rs7579899 (<i>EPAS1</i>), and rs35252396 (<i>PVT1/MYC</i>)-in a Spanish case-control cohort comprising 168 RCC patients and 259 healthy controls. This evidence concerns the gene ITPR2 and renal cell carcinoma.