Conversely, the apoptotic and inflammatory landscapes evolve significantly across age-groups; executioner caspase activity is highest in younger patients, while older cohorts and TNBC subtypes demonstrate a marked enrichment of anti-apoptotic BCL2, pro-apoptotic BAX, and the inflammatory mediator NF-κB.<h4>Conclusion</h4>Nigerian breast cancer exhibits profound molecular heterogeneity governed by both subtype and age. Here, NFKB1 is linked to breast cancer.