<h4>Background</h4>The purpose was to evaluate the diagnostic effectiveness of High-risk human papillomavirus(hrHPV) testing, DNA methylation, PAX1/ZNF671 methylation in triaging patients with abnormal cytology and/or abnormal cervical biopsy pathology in cervical cancer screening; And the detection performance of different screening strategies was compared among clinician-taken cervical scrapes and paired self-collected urine and vaginal samples.<h4>Methods</h4>A total of 136 urine-based,137self-collected vaginal and 140 cervical scrapes samples were analyzed. Here, ZNF671 is linked to cervical cancer.