In a syngeneic melanoma model, huFKBP5<sup>+/-</sup> mice presented a potent antitumor response characterized by reduced tumor growth, increased lymphocyte infiltration, elevated levels of cytotoxic markers (perforin, Bax, cleaved caspase-3 and -7, gasderminE), and the upregulation of CCR7 and CXCR5 on tumor-infiltrating lymphocytes. This evidence concerns the gene PRF1 and melanoma.