We introduce a novel gene-specific transcription network analysis that linked individual tau and amyloid connectomes to a common transcriptomic profile of apoptosis, with the tau connectome being specifically related to pyrimidine metabolism, and the amyloid connectome to histone acetylation.<h4>Discussion</h4>Individual molecular connectome mapping provides a novel and sensitive framework to monitor AD progression. The gene discussed is MAPT; the disease is Alzheimer disease.