Transcriptomic analysis identified three genes-ANKRD22, FCGR1A, and NOG-with differential expression in both conditions, highlighting the TGF-β/BMP signaling pathway and immune regulatory network as shared molecular underpinnings.<h4>Conclusion</h4>This study provides the first evidence of a significant association between sarcoidosis and ischemic stroke in a large cohort. Here, ANKRD22 is linked to ischemic stroke.