The role of PPME1 in tumor progression was evaluated <i>in vitro</i> using CCK-8, colony formation, wound healing, and Matrigel transwell assays, and <i>in vivo</i> using xenograft tumor models.<h4>Results</h4>Our pan-cancer analysis demonstrates that PPME1 is upregulated in the majority of tumors and exhibits heterogeneous expression across immune and molecular subtypes. Here, PPME1 is linked to neoplasm.