UBASH3B was further identified as a core prognostic biomarker, significantly promoting the proliferation and migration of pancreatic cancer cells, while bioinformatic analysis also suggested its association with tumor immune regulation pathway.<h4>Conclusion</h4>Our study develops a novel prognostic framework for patient stratification based on disulfidptosis-related genes in PDAC. Here, UBASH3B is linked to familial pancreatic carcinoma.