Nine protein targets were identified from the intersection of gene lists with high relevance to insulin resistance from GeneCards and DisGeNET and the target genes predicted by reverse screening using Swiss Target Prediction: protein-tyrosine phosphatase 1B (PTPN1), 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1), peroxisome proliferator-activated receptor α (PPARα), peroxisome proliferator-activated receptor γ (PPARγ), PI3-kinase p85-alpha subunit (PIK3R1), insulin receptor (INSR), tumor necrosis factor α (TNF-α), endothelial nitric oxide synthase (eNOS) and hepatic lipase (LIPC). This evidence concerns the gene NOS3 and Insulin resistance.