Moderation analyses assessed the interaction between reproductive variables and APOE ε2, ε3, and ε4 alleles, and were followed by simple slope analyses to clarify the direction of significant effects.<h4>Results</h4>AD females exhibited later ANM (50.3 ± 4.4 vs. 48.3 ± 6.2 years; <i>p</i> = 0.004) and longer reproductive lifespan (37.4 ± 4.4 vs. 35.4 ± 6.0 years; <i>p</i> = 0.005) than controls. This evidence concerns the gene APOE and Alzheimer disease.