CD4 and Fever: The sequential pathology, BTV localization by immunohistochemistry, BTV quantification by quantitative PCR (qPCR), immune cell kinetics [CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes in peripheral blood mononuclear cells (PBMCs), prescapular lymph node (PSLN), and spleen] by fluorescence-activated cell sorting (FACS), and cytokine estimation by qRT-PCR were studied.<h4>Results</h4>The BTV-24-infected animals showed pyrexia, conjunctival and oral mucosal congestion, cyanosis of tongue, serous to catarrhal nasal discharge, and viremia.