Subgroup analysis further revealed that patients with early-onset preeclampsia exhibited significantly higher CYPA levels in both trimesters when compared to those with late-onset preeclampsia (p < 0.05).<h4>Conclusion</h4>Cyclophilin A levels were higher in the first trimester in women who later developed preeclampsia and remained elevated in the third trimester in women with established disease. Here, PPIA is linked to preeclampsia.