This study aimed to provide a comprehensive description of SAI, identify independent risk factors, and develop a predictive nomogram for its early identification.<h4>Methods</h4>This study included 836 AIS patients of the Dalian Single-center Study on Intravenous Thrombolysis for Ischaemic Stroke (DATIS) cohort who received recombinant tissue-plasminogen activator-induced thrombolysis at Central Hospital of Dalian University of Technology between January 2018 and November 2021. This evidence concerns the gene PLAT and ischemic stroke.