CD161 (Cluster of differentiation 161) and its ligand Lectin-like transcript 1 (LLT1) have recently emerged as a novel immune-regulatory axis that modulates natural killer (NK) and T cell-mediated function in cancer and inflammatory conditions, but their expression in RS cells and association with HL patients' clinical-pathological features remain poorly defined.<h4>Methods</h4>In this study, 60 formalin-fixed paraffin-embedded (FFPE) tissue samples were collected from patients in Northern Jordan. This evidence concerns the gene CLEC2D and cancer.