mutans</i> biofilm formation <i>in vitro</i> and reduced moderate dentinal caries by >60% in rats.<h4>Conclusion</h4>Bacterial antigens can be effectively delivered via mRNA platforms, and Fc fusion is a promising strategy to enhance mucosal immunity against oral, respiratory, and other mucosal pathogens, consistent with Fc-FcRn-mediated mechanisms. The gene discussed is FCGRT; the disease is dental caries.