Cluster 3 was a metabolic risk subtype, characterized by relatively younger age, elevated TG, CHOL, HDL-C, LDL-C, APOB, APOA-1 and APOB/APOA1 ratio, and intermediate inflammatory activity.<h4>Conclusion</h4>Data driven clustering identified biologically distinct ischemic stroke subtypes based on inflammation, coagulation, and metabolic profiles. Here, APOA1 is linked to ischemic stroke.