<h4>Background</h4>Little is known regarding the expression patterns of adipose tissue proteins in the context of vitamin D deficiency and whether these expression patterns have adverse effects on fat-related diseases.<h4>Methods</h4>This study compares vitamin D receptor-knockout (VDRKO) and wild-type (WT) mice to determine whether the VDRKO affects the adipose tissue landscape. The gene discussed is VDR; the disease is vitamin D deficiency.