RESULTS: Lnc-HNRNPUL2 and TGF-β expression levels were significantly upregulted in the sera of CRC patients compared to controls, along with a concurrent decrease in the expression of miR-335-5p and SFTPD mRNA in the CRC group relative to both benign and healthy control groups Interestingly, lnc-HNRNPUL2 and hsa-miR-335-5p had significant predictive values for CRC diagnosis due to their high sensitivities and specificities (AUC = 0.901 and 0.877, respectively). This evidence concerns the gene TGFB1 and colorectal carcinoma.