Hence, we hypothesized that the Ca<sup>2+</sup>-sensitive membrane repair protein dysferlin is crucial for preserving sarcolemmal nanodomains in the MI border zone, like the transverse-axial tubule (TAT) network and the intercalated disc (ICD) membrane folds, and thereby limits the post-MI loss of myocardial function. The gene discussed is DYSF; the disease is myocardial infarction.