The area under the receiver operating characteristic (ROC) curve (AUC) for the combined serum sCD40L, CCL3, and NT-proBNP levels was greater than that of each individual marker (Z values: sCD40L = 3.337, CCL3 = 2.303, and NT-proBNP = 5.156; p < 0.001, p < 0.001, and p = 0.021, respectively).<h4>Conclusion</h4>Elevated serum sCD40L, CCL3, and NT-proBNP levels were associated with LLVT in elderly patients with HF. The gene discussed is NPPB; the disease is hydrops fetalis.