Logistic regression analyses were conducted to identify associations between systemic and dental disease phenotypes.<h4>Results</h4>Associations were observed between SNPs in MMP9 with systemic disease phenotypes (asthma, obesity, rheumatoid arthritis/autoimmune disease, and type II diabetes mellitus) without oral disease phenotypes (TMS-, PD-) (p = 0.00004). This evidence concerns the gene MMP9 and asthma.