Univariate Cox, Minimum Absolute Contraction and Selection Operator (LASSO) regression and risk scoring analysis divided TCGA-CRC patients into high- and low-risk cohorts.<h4>Results</h4>The prognostic genes <i>LMNB2</i>, <i>CASP7</i>, <i>PRKCB</i>, <i>GZMB</i> and <i>ENDOG</i> were identified, and the survival rate of high-risk patients was poor. The gene discussed is CASP7; the disease is colorectal carcinoma.