In summary, this study demonstrated that OMT inhibits <i>Malassezia</i> biofilm formation and ameliorates <i>Malassezia</i>-associated psoriasis by modulating oxidative stress, inflammation, and apoptosis via STAT3/Nf-κB and AhR/Nrf2 pathways. Here, NFKB1 is linked to psoriasis.