Druggability profiling with DrugnomeAI highlighted <i>CASP1, FAS, PSMB9</i> and <i>PRKACB</i> as experimentally tractable and pharmacologically actionable targets, and DGIdb suggested multiple repurposable agents against these nodes.<h4>Conclusion</h4>This study delineates extensive perturbations and crosstalk among apoptosis, pyroptosis and necroptosis in DKD, positioning PANoptosis as a unifying driver of tubulointerstitial injury. This evidence concerns the gene CASP1 and diabetic kidney disease.