KO mice showed hypoimmunity with premature tryptophan-kynurenine shift, glutathione and proline synthesis defects, etc. Oxidized glutathione and kynurenine correlated significantly with immune checkpoint LAIR-1, or viral TCID<sub>50</sub>.<h4>Discussion</h4>These findings demonstrate that CRP deficiency or human CRP transgenic induces distinct metabolic reprogramming post-infection. This evidence concerns the gene CRP and infection.