CDC25B and central nervous system cancer: Functional enrichment analysis was conducted to explore potential therapeutic targets.<h4>Results</h4>The AIDPI model identified nine key genes (GRIA1, ZNF165, TM9SF2, PRKAR2A, PSMD6, H1F0, CDC25B, HIST1H2AE, and NCAPD2) that were consistently associated with prognosis across multiple pediatric glioma datasets.