Functional enrichment analysis was conducted to explore potential therapeutic targets.<h4>Results</h4>The AIDPI model identified nine key genes (GRIA1, ZNF165, TM9SF2, PRKAR2A, PSMD6, H1F0, CDC25B, HIST1H2AE, and NCAPD2) that were consistently associated with prognosis across multiple pediatric glioma datasets. This evidence concerns the gene PRKAR2A and glioma.