TP53 and neoplasm: The updated paradigm about the origin of high-grade serous carcinoma (HGSC) suggests that many HGSCs derive from the fallopian tubes following a sequential tumor progression, from pathologically defined p53 signature, serous tubal intraepithelial lesion, and serous tubal intraepithelial carcinoma (STIC) to HGSC that later spreads to ovarian tissues and disseminates.