ACE and obesity due to melanocortin 4 receptor deficiency: This study utilizes an <i>ex vivo</i> translational model to clarify the sex-specific effects of ACE on AT metabolic and inflammatory profile of a vulnerable human substrate, such as the visceral AT of subjects with severe obesity.<h4>Methods</h4>Twenty-four subjects with severe obesity (11 men and 13 women) undergoing bariatric surgery were recruited from St.