Multiple regression analysis was performed to evaluate the relationships among thyroid dysfunction, inflammatory parameters, and indices of both metabolic and ovarian function.<h4>Results</h4>Both SCH and TAI independently increased TNF-α concentrations across the entire cohort (p=0.005 and p=0.018) and within the PCOS arm (p=0.018 and p=0.039). This evidence concerns the gene TNF and polycystic ovary syndrome.