STX4 and type 1 diabetes mellitus: Integrated transcriptomics and proteomics analyses showed that STX4 represses senescence-related transcriptional programs and reshapes the β-cell secretome, including enrichment of proteins involved in purine ribonucleotide metabolism.<h4>Discussion</h4>These findings indicate that STX4 protects β-cells from cytokine or bleomycin-induced senescence and suggest that enhancing STX4 activity may be a therapeutic strategy to preserve functional β-cell mass in T1D.